Lacey Chabert

Eliza Thornberry (voice)

Jodi Carlisle

Marianne Thornberry (voice)

Tim Curry

Nigel Thornberry (voice)

Flea

Donald 'Donnie' Michael Thornberry (voice)

Danielle Harris

Debbie Thornberry (voice)

Tom Kane

Darwin (voice)

Betty White

Grandma Sophie (voice)

Alan Henry Brown

Sri Mayasandra (voice)

Arthur Burghardt

Rhino / Monkey (voice)

Cara DeLizia

Baru / Monkey (voice)

Moira Quirk

Rehabilitation Worker / Monkey (voice)

Dwight Schultz

Badouk / Monkey / Poacher (voice)

Tuan Tran

Kickboxing Instructor (voice)

Alfre Woodard

Medicine Woman (voice)

Dee Bradley Baker

Parrots (voice)

Ron Noble

Carol Millican

Joseph Scott

Dean Criswell