Haley Joel Osment

Edwurd Fudwupper (voice)

Frances McDormand

The Adult Fannie (voice)

Emily Osment

The Child Fannie (voice)

John Cleese

The Giant Alien (voice)

Jonathan Winters

The President

Catherine O'Hara

Lorna Mae Loon (voice)

Harry Shearer

The General (voice)

Justin Brinsfield

Mabel Dill (voice)

Berkeley Breathed