Fred Savage

Garfield 'Garf' Jerrniga

Ray Walston

Matt

Sara Gilbert

Stephie

John Clark Matthews

Ralph the Mouse (Voice)

Conchata Ferrell

Aunt Jill

Kellie Martin

Karen

Summer Phoenix

Lana

Anne Bloom

Garf's Mother

Bruce French

Garf's Father

Hal Smith

Night Clerk

June Foray

Sister Mouse (Voice)

Katie Leigh

Cousin Mouse (Voice)

Corey Burton

Chum (Voice)

Billy Barty

Uncle Lester (Voice)

E'Lon Cox

Jonathan

Ron Underwood