David Duchovny

Gus

Nicky Katt

Hitler

Catherine Keener

Lee

Mary McCormack

Linda

David Hyde Pierce

Carl

Julia Roberts

Francesca / Catherine

Blair Underwood

Calvin / Nicholas

Enrico Colantoni

Arty / Ed

Erika Alexander

Lucy

Tracy Vilar

Heather

Brandon Keener

Francesca's Assistant

Jeff Garlin

Harvey, probably

David Alan Basche

Nicholas's Agent

Terence Stamp

Man on Plane / Self

Nancy Lenehan

Woman on Plane

Steven Soderbergh