Clive Brook

Sherlock Holmes

Miriam Jordan

Alice Faulkner

Ernest Torrence

Professor James Moriarty

Herbert Mundin

George

Reginald Owen

Dr. Watson

Alan Mowbray

Colonel Gore-King

C. Montague Shaw

Judge

Ivan F. Simpson

Faulkner

Roy D'Arcy

Manuel Lopez (uncredited)

John George

Bird Shop Thug (uncredited)

Brandon Hurst

Secretary to Erskine (uncredited)

Howard Leeds

Little Billy

William K. Howard