Babe Ruth

Babe (as George Herman 'Babe' Ruth)

Ruth Taylor

Mildred Tobin

William Sheer

Harry Knight

Margaret Seddon

Babe's Mother

Frances Victory

Pigtails

James A. Marcus

Simon Tobin

Ralf Harolde

John Tobin (as Ralph Harolds)

Charles Byer

David Talmadge (as Charles Burt)

George Halpin

Doc Hedges / The Constable / Dog Catcher

William J. Gross

Eliar Lott

Walter Lawrence

Tony Marino

Ann Brody

Mrs. Tony Marino (as Anne Brodie)

Ricca Allen

Almira Worters

Sammy Blum

Jimbo Jones (as Sam Blum)

Ethel Kerwin

Kitty Wilson

Lawrence C. Windom