Sarah Silverman

Self

Nathan Barnatt

Homeless Man (segment "Lisa")

Lauren Lapkus

Girl 5 (segment "Lisa")

John C. Reilly

Father (segment "Ham")

Laura Silverman

Self (segment "Knickers")

Seth Rogen

Officer Durand (segment "Knickers")

Jade Catta-Preta

Mother (segment "Lisa")

Natasha Leggero

Girl 2 (segment "Lisa")

Shelby Fero

Girl 1 (segment "Lisa")

Nathan Fielder

Self (segment "Retro Video Arcade")

David Dineen-Porter

Self (segment "Retro Video Arcade")

Kyle Dunnigan

Self

Michael Daniel Cassady

Self (segment "Lisa")

Brett Gelman

Self

Emily Maya Mills

Girl 6 (segment "Lisa")

Mike Relm

Richard Schreiber

Ryan Polito

David Dineen-Porter

Stoney Sharp

Dean Fleischer Camp

Andrew DeYoung

Charlyne Yi

Rob Schrab

Eric Wareheim