Arthur Wontner

Sherlock Holmes

Lyn Harding

Prof. Moriarty

Leslie Perrins

John Douglas

Ian Fleming

Dr. John Watson

Charles Mortimer

Insp. Lestrade

Minnie Rayner

Mrs. Hudson

Michael Shepley

Cecil Barker

Jane Carr

Ettie Douglas

Ben Welden

Ted Balding

Roy Emerton

Boss McGinty

Wilfrid Caithness

Col. Sebastian Moran

Conway Dixon

Ames

Edmund D'Alby

Captain Marvin

Ernest Lynds

Jacob Shafter

George Spence

Scowrer (uncredited)

Leslie S. Hiscott