Emmanuelle Vaugier

Jane Browning / Painkiller Jane

Eric Dane

Nick

Richard Roundtree

Colonel Watts

Venus Terzo

Carla Browning

Walker Howard

Blue

Callum Keith Rennie

Mitchell

Tate Donovan

Dr. Graham Knight / Lucas Insley

Paula Brancati

Young Jane

Elicia Mackenzie

Young Carla

Martin Cummins

Sergeant Flynn

Richard Harmon

Squeak

Sanford Bookstaver