Dominic Purcell

John Doe

Jayne Brook

Jamie Avery

John Marshall Jones

Frank Hayes

William Forsythe

Digger

Rekha Sharma

Stella

Sprague Grayden

Karen Kawalski

Michelle Hart

Nance Fenton

David James Lewis

Stu

Grace Zabriskie

Yellow Teeth

Gary Werntz

Trenchcoat

David Parker

Detective Roosevelt

Claudette Mink

Turquoise (uncredited)

Dion Luther

Broker

Adam Henderson

Medical Examiner

Meshach Peters

Tyler Hayes

Mike Thompson

Brandon Camp